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Dendritics.jpg

Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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R&D Systems.jpg

R&D Systems位于美国的明尼苏达州,一直致力于生物制品的开发与生产。公司成立之初主要生产用于医院及临床应用的血控品。1977年,公司推出第一个产品--富血小板血浆质控品;1981年,公司成为全球第二家生产含血小板全血控品的供应商。40多年的发展中,R&D Systems仍持续开发各种血控品产品。

 

1985年,作为公司推出的第一个科研试剂产品,也是全球第一家将该产品进行商业化生产的产品,R&D Systems成功上市了TGF-beta1蛋白。作为胞外信号分子,TGF-beta1蛋白在多种细胞中进行表达,并作为胞外信号分子参与免疫功能,细胞增殖和细胞分化等生物学过程。该产品推出后,公司陆续从生物材料中纯化了几种细胞因子产品并推向市场。天然蛋白类产品的成功推广,加速了R&D Systems在细胞因子市场的开拓。公司于1985年形成Growth Factor事业部(现Biotechnology事业部)。Biotechnology事业部的目标是生产和营销重组人细胞因子。与天然来源提取蛋白相比较,DNA重组技术生产的蛋白产品其成本更低,产量更高,完全摆脱原料的限制。1989年,Biotechnology事业部开始开发抗细胞因子的单克隆和多克隆抗体,并于1990年开发了第一个ELISA试剂盒。

 

R&D System的主要产品包括:

Recombinant Proteins

GMP Proteins

Antibodies

ELISAs

Luminex Assays & High Performance Assays

Stem Cell Products

Cell Culture

Small Molecules & Peptides

Enzymes

ELISpots

cDNA Clones

Flow Cytometry Workflow Solutions

Proteome Profiler Antibody Arrays

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SERO生产以下系列专利产品Seronorm™, Pathonorm™ and Autonorm™。除此之外,也为客户提供个性化定制产品。

 

Seronorm™系列

主要产品包括免疫对照,结合激素,心脏和肿瘤标志物,Seronorm™所有对照血清来源为人,不含防腐剂和稳定剂,产品文档全面,为市场上最常用的仪器提供超过50种分析物的分配值,可提供四个不同临床级别,且每一级别都可单独提供。Seronorm™ Immunoassay Liq low – 含有与临床相当的低水平的醛固酮,雄烯二酮,皮质醇,铁蛋白,IgE,17-OH-孕酮,PSA总量,睾酮,游离T4,TSH,25-OH-维生素D和维生素B12

 

Pathonorm™ and Autonorm™

Pathonorm™临床化学级对照,不含防腐剂和稳定剂的动物血清,适合大部分临床化学分析,为市面上常用仪器提供超过38种分析物的分配值,有两种临床级别,且都可以单独提供,产品以冻干粉形式提供,货架期长。

 

Autonorm™

满足绝大部分临床化学实验室正常水平的分析级的高品质对照,不含防腐剂和稳定剂的动物血清,不含Pharmaca。文档齐全,为市场上最常用的仪器提供超过30种分析物的分配值,冻干粉,货架期长。

 

客户定制产品:

SERO也针对有质量意识的诊断公司,组织提供定制服务,SERO可定制的高品质对照产品如下:

常规血清化学(人或动物基质)

常规尿液化学

脂质

激素

肿瘤标记

心脏标志物

蛋白质

治疗药物

专业和护理点控制(CRP,HbA1C,血红蛋白,葡萄糖)

微量元素和重金属

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艾美捷科技代理PRIMACYT品牌全系列产品


PRIMACYT是专注于体外技术领域的一家德国公司。PRIMACYT公司致力于通过高度模拟人体生物学特性的细胞培养平台,提供肝脏、皮肤和血液衍生的生物学检测系统,广泛应用于人类和动物健康以及环境安全测试领域。公司核心业务涵盖肝细胞、肝脏亚细胞组分、皮肤组织、血液衍生产品及细胞培养基等关键技术产品。


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▍PRIMACYT产品线

人和动物源的原代肝细胞及肝脏亚细胞组分(部分产品列表)

PRIMACYT提供全球最大的肝脏衍生体外系统产品组合,包括高质量的原代肝细胞及肝脏亚细胞组分,细胞来源涵盖人类、啮齿动物、农场动物,鸟类及鱼类。这些细胞可用于药物代谢、毒性研究和药物筛选。

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品名货号产品描述
Human hepatocytesHHCSHuman Hepatocytes Cryopreserved for use in Suspension
Human hepatocytesHHCPHuman Hepatocytes Cryopreserved Plateable
Human hepatocytesHHCP-IHuman Hepatocytes Cryopreserved Plateable, Cytochrome P450 inducible
Human non-parenchymal liver cellsHLSECHuman liver sinusoidal endothelial cells cryopreserved
Cryopreserved Mouse HepatocytesMHCP-I-3DMouse Hepatocytes Cryopreserved Plateable, Cytochrome P450 inducible, Suitable for 3D culture
Cryopreserved Mouse HepatocytesMHCP-IMouse Hepatocytes Cryopreserved Plateable, Cytochrome P450 inducible
Cryopreserved Mouse HepatocytesMHCPMouse Hepatocytes Cryopreserved Plateable
Wistar Han Rat Liver CellsWH-RHCP-I-3DWistar Han rat hepatocytes cryopreserved plateable, Cytochrome P450 inducible, suitable for 3D spheroid cultures
Wistar Han Rat Liver CellsWH-RHCP-IWistar Han rat hepatocytes cryopreserved plateable, Cytochrome P450 inducible
Wistar Han Rat Liver CellsWH-RLKCWistar Han rat liver Kupffer cells cryopreserved
Wistar Han Rat Liver CellsWH-RLSCWistar Han rat liver Stellate cells cryopreserved
Sprague Dawley Rat Liver CellsSD-RHCP-ISprague Dawley rat hepatocytes cryopreserved plateable, Cytochrome P450 inducible
Sprague Dawley Rat Liver CellsSD-RLKCSprague Dawley rat liver Kupffer cells cryopreserved
Sprague Dawley Rat Liver CellsSD-RLNPCSprague Dawley rat liver nonparenchymal cells cryopreserved
Cryopreserved Rabbit HepatocytesNZL-RabHCP-INew Zealand White Rabbit Hepatocytes Cryopreserved Plateable, Cytochrome P450 inducible
Cryopreserved Rabbit HepatocytesRabHCP-IDomestic Rabbit Hepatocytes Plateable, Cytochrome P450 inducible
Cryopreserved Cynomolgus HepatocytesCHCP-I-3DCynomolgus hepatocytes cryopreserved plateable Cytochrome P45o inducible and 3D (Spheroid culture) qualified



● 原代皮肤细胞和人离体皮肤组织

PRIMACYT提供人源和动物源的皮肤成纤维细胞和角质形成细胞的原代皮肤细胞,这些细胞可应用于皮肤毒性研究、药物递送系统评估和皮肤相关疾病模型的研究。具体应用包括:局部药物的表征;生物杀菌剂、农业化学品的安全评估;化妆品成分的安全性评估;基于物质的医疗器械分类。


品名货号产品描述
Skin tissues (human)H-skinHuman Skin
Skin discs & dermatomed skinH-skin disc-
Skin discs & dermatomed skinH-skin sheet-
Human and Cynomolgus FibroblastsNHDF-ADNormal Human Dermal Fibroblasts, adult donor
Human and Cynomolgus FibroblastsNHDF-JFNormal Human Dermal Fibroblasts, juvenile foreskin
Human and Cynomolgus FibroblastsNCDFNormal Cynomolgus Dermal Fibroblasts
KeratinocytesNHEK-JFNormal Human Epidermal Keratinocytes, juvenile foreskin donor


● 血液制品

包括来自健康人类和动物来源的血液制品,如全血、血浆、外周血单核细胞、血沉棕黄层等。这些血液制品可广泛应用于血液相关疾病的研究、免疫反应评估以及其他毒理学研究。

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品名货号产品描述
PMBC - Peripheral Blood Mononuclear Cell (human)HPBMChuman PBMC
PMBC - Peripheral Blood Mononuclear Cell (rat)SD-RPBMC-poolSprague Dawley Rat PBMC
PMBC - Peripheral Blood Mononuclear Cell (rat)SD-RPBMC-single donorSprague Dawley Rat PBMC
PMBC - Peripheral Blood Mononuclear Cell (rat)WH-RPBMC-poolWistar Han Rat PBMC
PMBC - Peripheral Blood Mononuclear Cell (rat)WH-RPBMC-single donorWistar Han Rat PBMC
PMBC - Peripheral Blood Mononuclear Cell (mouse)MPBMC-poolmouse PBMC


 实验消耗品(Consumables)

PRIMACYT提供定制化的细胞培养基、试剂盒和细胞培养板,支持各种细胞的生长和功能维持。PRIMACYT的培养基专为优化细胞活性和功能设计,适用于不同动物来源的肝细胞的解冻、贴壁和培养,满足长期培养、药物筛选和毒性评估等多种实验需求。


分类货号
产品描述
3D Hepatocytes Maintenance Medium3D-HMM-500S3D-Hepatocyte Maintenance Medium
3D Hepatocytes Maintenance Medium3D-HMM-5003D-Hepatocyte Maintenance Medium
3D Hepatocytes Maintenance Medium3D-HMM-2503D-Hepatocyte Maintenance Medium
Long Term Hepatocyte Culture Medium (HHMM)HHMM-500SHuman Hepatocyte Maintenance Medium
Long Term Hepatocyte Culture Medium (HHMM)HHMM-500Human Hepatocyte Maintenance Medium
Long Term Hepatocyte Culture Medium (HHMM)HHMM-250Human Hepatocyte Maintenance Medium
Long Term Hepatocyte Culture Medium (HHMM)ACF-HHMM-500SAnimal Component Free Human Hepatocyte Maintenance Medium
Long Term Hepatocyte Culture Medium (HHMM)ACF-HHMM-500Animal Component Free Human Hepatocyte Maintenance Medium
Long Term Hepatocyte Culture Medium (HHMM)ACF-HHMM-250Animal Component Free Human Hepatocyte Maintenance Medium
Long Term Hepatocyte Culture Medium (HHMM)FHM-
Long Term Hepatocyte Culture Medium (HHMM)FGM-500-
Short Term Hepatocyte Culture Medium (HM)HM-500Hepatocyte Medium
Short Term Hepatocyte Culture Medium (HM)HM-250Hepatocyte Medium
Thawing and Plating KitsPTK-1Thawing and Plating of Cryopreserved Hepatocytes
Thawing and Plating KitsPTK-2Thawing and Plating of Cryopreserved Hepatocytes from Rat and Minipig
Thawing and Plating KitsPTK-NPCThawing and Plating of Cryopreserved Non-parenchymal liver cells
Thawing and Plating KitsTK-1Thawing Kit Cryopreserved Mammal Hepatocytes Suspension Assays
Thawing and Plating KitsTK-FHSAThawing Kit Cryopreserved Fish Hepatocytes Suspension Assays
Collagen ProductsCCP-06Cell culture plate coated with rat tail collagen,6well, Package of 5
Collagen ProductsCCP-12Cell culture plate coated with rat tail collagen,12well, Package of 5
Collagen ProductsCCP-24Cell culture plate coated with rat tail collagen,24well, Package of 5
Collagen ProductsCCP-96Cell culture plate coated with rat tail collagen,96well, Package of 5
Collagen ProductsRTC-100Rat Tail Collagen Type I,3mg/ml, 100 ml
BIOFLOAT™ ULA platesBioFloat™ SeriesBioFloat™ 96 well plate,ready to use


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